Novel 1,726 nm laser system offers selective sebaceous gland photothermolysis for acne

Dr. Emil A. Tanghetti, Photo courtesy of the American Society for Laser Medicine and Surgery

A recent study highlights a significant advancement in the treatment of acne using a novel 1,726 nm laser system. Published in Lasers in Surgery and Medicine, this innovative approach—combining state-of-the-art technology with thermal imaging and software algorithm-assisted controls—achieved selective photothermolysis of sebaceous glands without causing significant damage to surrounding skin structures.

Led by Dr. Emil A. Tanghetti, a dermatologist based in Sacramento, Calif., the researchers designed and built the 1,726 nm laser system with a 40W maximum power output, a controlled bulk air-cooling device, and a thermal camera in the handpiece.

Unlike previous laser treatments that often relied on single or dual pulses, this multi-pulse protocol effectively damages the sebaceous glands while preserving the epidermis. Thermal imaging plays a crucial role in controlling pulse delivery, ensuring that the treatment reaches the ideal temperature and depth, and providing a safe, effective, and durable response against acne.

"The laser treatment of acne has always been an aspirational goal of our team. From the basic science to the construction of the device, our team has devoted our efforts over the last nine years to construct a device that would treat acne with a durable response," Dr. Tanghetti noted in a press release from the American Society for Laser Medicine and Surgery, Inc. (ASLMS). "We employed new ways to use air cooling, thermal imaging, and software algorithms to bring this state-of-the-art device to the marketplace."

The researchers say this treatment is suitable for all skin types, including skin of colour. Real-time temperature monitoring not only enhances safety but also allows for precise targeting based on anatomical variations rather than skin type.

The system offers different protocols for different levels of patient discomfort that permit optimal mitigation of pain (injectable vs. topical anesthesia).

The authors suggest that the technological advancements in this device could have broader applications for thermally based treatments, improving both patient safety and efficacy.

Dr. Tanghetti is an Associate Editor of Lasers in Surgery and Medicine, the official journal of ASLMS. The study was selected as the March 2025 Editor’s Choice, reflecting its significance in the field of laser medicine.