BMAL1 (green) and YAP1 (red) in the adult (top) and aged (bottom) epidermis. Cell nuclei appear in blue. Image courtesy the Institute for Research in Biomedicine, Barcelona A new study describes a molecular mechanism that helps explain the drivers of persistent low-grade inflammation that impairs skin regeneration as humans age. Findings show that during aging, two proteins, BMAL1 and YAP, change how they work together and increase the activity of inflammatory genes in the ep

Zasocitinib is effective in improving skin clearance for PsO patients in hard-to-treat areas with once-daily treatment

Under normal conditions (left), melanocytes adhere to laminin-211 in the basement membrane through dystroglycan, maintaining their mature pigment-producing state. In vitiligo (right), remodeling of the basement membrane increases laminin-332 and promotes integrin α3β1-mediated adhesion, activating signalling pathways, including c-Jun, that drive melanocyte dedifferentiation and loss of pigment production. Image courtesy Osaka Metropolitan University Researchers report that pi

Robert Harmon, PhD, research assistant professor of Pathology. Photo courtesy Northwestern University Researchers have identified a mechanism that may explain why people with the genetic skin disorder Darier disease often develop symptoms years after birth and experience painful flares triggered by heat, sunlight, and psychological stress. The findings, published in Science Advances, point to oxidative stress and impaired cellular defences as central drivers of Darier disease

Povorcitinib is effective in treating patients with moderate-to-severe HS

An AI-guided network analysis of genomic data (left) highlights two protein targets, including the oxytocin receptor, identified through Biohub’s CRISPR screen in primary human skin cells (right). Image by Zhao, C., Shih, M., Ahmed, S. et al. Nat Commun (2026). Researchers have combined genome-wide CRISPR screening with artificial intelligence to identify two unexpected therapeutic targets for psoriasis, opening a possible path toward topical treatments that avoid systemic im

Researchers at The University of Texas MD Anderson Cancer Center have discovered that immunosuppressed patients with non-melanoma skin cancer are not missing the key cancer-fighting macrophages found in immunocompetent patients. Instead, those cells have lost the ability to communicate effectively. The researchers say this new understanding may help researchers develop new treatment approaches for these aggressive skin cancers. The study was published in Cell. Moran Amit, MD,

Oral antihistamines show little meaningful benefit for AD and can even increase the risk of cognitive impairment in some patients